Liverpool look to end winless streak
With identical records after five games, the two Manchester clubs are setting the early pace in the Premier League and this weekend take on opponents who have had problems scoring.
Second-place United travel to Southampton, who have failed to score in four of their six games in all competitions this season.
City and United will be up against packed defences but have already scored 16 goals each this season.
Third-place Chelsea are at Stoke, while Liverpool look to end a four-match winless run since returning from the international break when they visit Leicester. The two teams met in the League Cup on Tuesday, with Leicester winning 2-0.
West Bromwich Albion midfielder Gareth Barry is set to make a record 633rd Premier League appearance, passing the mark he holds alongside Manchester United great Ryan Giggs, in a match at Arsenal on Monday.